DNA Cleavage Promoted by Cu2+ Complex of N,N'-Bis(2-aminoethyl)-2,6-pyridinedicarboxamide

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2007,（7）
• 页码范围: 937-941
• 页数: 5页
• 语种: 英文

摘要

The interaction of Cu2+ complex of N,N'-bis(2-aminoethyl)-2,6-pyridinedicarboxamide (BAP) with DNA was studied by agarose gel electrophoresis analysis. The results indicate that the BAP-Cu2+ complex can promote the cleavage of phosphodiester bond of supercoiled DNA at physiological condition, which is 3.2×106 times higher than DNA natural degradation. A hydrolytic cleaving mechanism through the cooperation of copper ions and functional amino groups was proposed.