Highly Efficient Pd/C-Catalyzed Suzuki Coupling Reaction of p-(un)Substituted Phenyl Halide with (p-Substituted phenyl) Boronic Acid

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2007,（8）
• 页码范围: 1183-1186
• 页数: 4页
• 语种: 英文

摘要

A highly efficient Pd/C-catalyzed ligandless, heterogeneous Suzuki reaction of p-(un)substituted phenyl halide with (p-substituted phenyl)boronic acid in DMF/H2O solvent in a short reaction time (0.5 h) at 75 ℃ was developed.The key for such a catalytic system was the addition of 1 equivalent of tetrabutylammonium bromide. A wide variety of substituents can be tolerated and high yields of cross coupling products were achieved. The palladium catalyst can be easily recovered and reused without significantly decreasing its efficiency.