A Convenient and Efficient Route to 1,4-Bis(heteroaryl)buta-1,3-diene and 4-Heteroarylbut-1-en-3-yne from 1,4-Dichlorobut-2-yne
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摘要:
A convenient and practical route to functionalized conjugated 1,3-enynes and 1,3-dienes is described.1,4-Bis(heteroaryl)-1,3-diene and 1-heteroarylbut-1-en-3-yne derivatives were prepared from 1,4-dichloro-2-buty'ne and corresponding N-heteroarenes such as imidazole, pyrrole, pyrazole and indole derivatives in the presence of bases in good to high yields.