First Synthesis of Bioactive Diphyllin Glycosides Isolated from Justicia patentiflor Hemsl

• 来源期刊: 中国化学(英文版)
• 年，卷（期）: 2007,（5）
• 页码范围: 679-682
• 页数: 4页
• 语种: 英文

摘要

The syntheses of three naturally occurring diphyllin glycosides have been achieved. 7-O-β-D-Quinovopyranosyldiphyllin (patentiflorin A) and 7-O-β-L-fucopyranosyldiphyllin (patentiflorin B) were synthesized by the glycosylation of diphyllin with peracetylglycosyl bromides under phase transfer catalysis (PTC) conditions.4"-O-Acetyl-7-O-β-L-fucopyranosyldiphyllin (4"-O-acetyl patentiflorin B) was obtained from patentiflorin B on an orthoesterification-orthoester rearrangement approach. Their 1H NMR, 13C NMR and HRMS signals are all consistent with those reported for the natural product.