Inhibition of Homo-coupling of Arylboronic Acids in Ligand Free Pd(Ⅱ)-Catalyzed Suzuki Reaction

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2007,（9）
• 页码范围: 1326-1329
• 页数: 4页
• 语种: 英文

摘要

A series of solvents were examined for the ligand free Pd(Ⅱ)-catalyzed Suzuki reaction of 4-bromotoluene with phenylboronic acid. It was found that the PdCl2/i-PrOH system could efficiently inhibit the homo-coupling of phenylboronic acid and give a cross-coupling product in high yields. The substrates with a wide variety of functional groups were tolerated in the system. A possible mechanism for this system was proposed.