Changes of Plasma Levels of Brain Natriuretic Peptide in Patients With Chronic Heart Failure before and after Carvedilol Treatment

• 来源期刊: 岭南心血管病杂志（英文版）
• 关键词: brain natriuretic peptide chronic heart failure left ventricular ejection fraction carvedilol
• 年，卷（期）: 2008,（3）
• 页码范围: 126-128
• 页数: 3页
• 语种: 英文

摘要

Objectives To investigate the changes of plasma brain natriuretic peptide (BNP) concentrations in patients with chronic heart failure (CHF) before and after carvedilol treatment. Methods Plasma BNP concentrations of patients with CHF (n = 56) before and after carvedilol treatment and of normal controls (n = 60) were measured with specific radioimmunoassay. Left ventricular ejection fraction of patients with CHF before and after carvedilol was measured with 99mTc gated cardiac blood pool scintigraphy. Results The results showed that plasma BNP concentrations of patients fractions (r = -0. 68 ,P <0. 01). After three months treatment of carvedilol, plasma BNP concentrations fell to (79. 65(P <0. 01). Conclusions These results indicate that plasma BNP concentrations are increased in patients with CHF,and markedly increased according to the severity of heart failure classified by NYH classification. Carvedilol can markedly decrease plasma BNP concentrations and improve left ventricular function in patients with CHD.