Positive Darwinian selection in human population: A review

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2008,（10）
• 页码范围: 1457-1467
• 页数: 11页
• 语种: 英文
• DOI: 10.1007/s11434-008-0202-z

摘要

This paper reviews a large number of genes under positive Darwinian selection in modern human populations, such as brain development genes, immunity genes, reproductive related genes, percep-tion receptors. The research on the evolutionary property of these genes will provide important insight into human evolution and disease mechanisms. With the increase of population genetics and com-parative genomics data, more and more evidences indicate that positive Darwinian selection plays an indispensable role in the origin and evolution of human beings. This paper will also summarize the methods to detect positive selection, analyze the interference factors faced and make suggestions for further research on positive selection.