EXPRESSION OF SURVIVIN, P53 AND ITS RELATIONSHIP WITH APOPTOSIS, PROLIFERATION IN HEPATOCELLULAR CARCINOMA(HCC)

• 来源期刊: 南京医科大学学报(英文版)
• 学科: 医学
• 年，卷（期）: 2008,（4）
• 页码范围: 255-259
• 页数: 5页
• 分类号: R73
• 语种: 英文

摘要

Objective:To investigate the expression of Survivin p53 and its relationship with apoptosis、proliferation in hepatocellular carcinoma(HCC). Methods:The expression of Survivin, p53 and the proliferation of tumor cells marked by proliferation cell nuclear antigen (PCNA) in 42 cases of HCC were assessed by immunohistochemical method. TUNEL was used to detect apoptosis. Results:Survivin protein was expressed in 30 of 42 cases of HCC(71.4%) and in 4 of 34 cases of adjacent cirrhosis tissues(11.8%). Expression of...