Photobleaching of Hypocrellin B and 2-Taurine Substituted Hypocrellin B in Plasma Solution

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2008,（3）
• 页码范围: 510-515
• 页数: 6页
• 语种: 英文

摘要

Photodynamic therapy (PDT) is a new methodology to utilize jointly a photosensitizer and light to destroy the target tissues of diseases via some photochemical reactions. On the other hand, the photosensitizer molecules may also be photo-bleached during PDT, furthermore, their interaction with biomolecules and the photobleaching properties in blood vessels are critical to treatments of microvascular diseases. In consideration of these, the photobleaching processes of HB and its analogue THB in plasma solutions were investigated in the current work. It was observed that the photobleaching was predominately mediated by singlet oxygen reactions in well-oxygenated aqueous solution in the presence of plasma substrate which not only greatly enhanced the photobleaching rate but also led to different photoproducts due to distinctly different reaction mechanisms. The relative photobleaching mechanisms were proposed based on the structural information and the redox potentials of the photosensitizers.