A Versatile Approach for the Total Syntheses of Fuscinarin and Fuscins

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2008,（4）
• 页码范围: 693-698
• 页数: 6页
• 语种: 英文

摘要

The first total synthesis of fuscinarin (1) and total synthesis of fuscins, the pentaketide metabolites showing activity against CCR5 in a scintillation proximity assay, were described by using compound 6 as a common intermediate. A key feature of the approach is the microwave-assisted tandem ortho-Claisen/Cope rearrangement that was used for the expedient synthesis of the intermediate 10.