Application of the phylogenetic analysis in mitochondrial disease study

• 来源期刊: 科学通报(英文版)
• 年，卷（期）: 2008,（18）
• 页码范围: 2733-2738
• 页数: 6页
• 语种: 英文
• DOI: 10.1007/s11434-008-0380-8

摘要

Mitochondrial disease currently received an increasing concern. However, the case-control design commonly adopted in this field is vulnerable to genetic background, population stratification and poor data quality. Although the phylogenetic analysis could help solve part of these problems, it has not received adequate attention. This paper is a review of this method as well as its application in mito-chondrial disease study.