A Facile Aqueous Synthesis of Bis(indol-3-yl)alkanes Cata-lyzed by Dodecylbenzenesulfonic Acid

• 来源期刊: 中国化学(英文版)
• 年，卷（期）: 2008,（12）
• 页码范围: 2228-2232
• 页数: 5页
• 语种: 英文

摘要

An environmentally friendly synthetic method for bis(indol-3-yl)alkane derivatives has been developed. In the presence of 10 mol% of dodecylbenzenesulfonic acid (DBSA), electrophilic substitution reaction of indoles with aldehydes or ketones proceeded smoothly in water, giving rise to the corresponding bis(indol-3-yl)alkanes in good to excellent yields. The use of inexpensive and easily available catalyst, mild reaction conditions and simple work-up procedure made this protocol practical and economically attractive.