Biomimetic Synthesis of Twenty-four Long-chained Diketones as Precursors for Muscone and Further Macrocyclic Ketones

• 来源期刊: 中国化学(英文版)
• 年，卷（期）: 2008,（12）
• 页码范围: 2249-2255
• 页数: 7页
• 语种: 英文

摘要

The one-carbon unit transfer reaction of tetrahydrofolate coenzyme was initiated. Bisbenzimidazolium salts were used as a tetrahydrofolate coenzyme model, and thus the biomimetic synthesis of twenty-four acyclic dike-tones as precursors for macrocyclic ketones was successfully accomplished by using the addition-hydrolysis reac-tion of the bisbenzimidazolium salts with alkyl magnesium halide, wherein six diketones have not been reported in literature. Accordingly, a short route to muscone analogues was provided.