Synthesis of Some Novel Phenyl Substituted Oxothiazolidin-1",3",4"-thiadiazolo-[3',4'-b]thiazoline of 3β-Substituted Cholestane

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2008,（7）
• 页码范围: 1339-1342
• 页数: 4页
• 语种: 英文

摘要

Three title compounds 4a-4e have been synthesized by the cyclodehydration of 1'-benzylidine-4'-(3β-substi-tuted-5a-cholestane-6-yl)thiosemicarbazones 2a-2c with thioglycolic acid followed by the treatment with coldconc. H2SO4 in dioxane. The compounds 2a-2c were prepared by condensation of 3β-substituted-5a-cholestan-6-one-thiosemicarbazones 1a-1e with benzaldehyde. These thiosemicarbazones 1a-1c were obtained by the reaction of corresponding 3β-substituted-5a-cholestan-6-ones with thiosemicarbazide in the presence of few drops of conc. HC1 in methanol. The structures of the products have been established on the basis of their elemental,analytical and spectral data.