An Environmentally Benign Access to Dimethylated 1,6-Dihydropyrimidines Using Dimethyl Carbonate as Methylating Agent under Microwave

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2008,（2）
• 页码范围: 368-372
• 页数: 5页
• 语种: 英文

摘要

An environmentally benign procedure for dimethylated 1,6-dihydropyrimidines has been developed by the reaction of 1,2,3,4-tetrahydropyrimidine-2-thiones with dimethyl carbonate, a non-toxic and environmentally friendly reagent.The methylation of 1,2,3,4-tetrahydropyrimidine-2-thione was promoted by MgO and tetrabutylammonium bromide (TBAB) under microwave.This protocol avoids the use of strong bases and highly toxic methylating agents such as methyl halide or dimethyl sulfate.Additionally, the possible role of MgO/TBAB in the reaction was also presented.