Immobilized Palladium on Organic-inorganic Hybrid Materials: A Novel and Reusable Catalyst for the Copper-Free Sonogashira Coupling Reaction

• 来源期刊: 中国化学(英文版)
• 年，卷（期）: 2008,（9）
• 页码范围: 1601-1606
• 页数: 6页
• 语种: 英文

摘要

The immobilized palladium on organic-inorganic hybrid materials catalyzing the copper-free Sonogashira cou pling reaction has been described.Terminal alkynes were reacted with aryl iodides and aryl bromides in the pres ence of 3-[N,N-bis(diphenylphosphino)amino]propyl functionalized silica gel immobilized palladium catalyst.The protocol involved the use of ethylene glycol as a solvent,and triethylamine as a base.The reactions generated the corresponding cross-coupling products in excellent yields.Furthermore,the silica-supported phosphine palladium complexes and ethylene glycol could be recovered and recycled for six consecutive trials without significant loss of their activity.