在织物损害的微型环境，为有效干细胞治疗的一个关键焦点: 间充质的干细胞的讨论

• 作者: Pranela Rameshwar
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: STEM cell therapy MICROENVIRONMENT MESENCHYMAL STEM cells IMMUNE responses
• 年，卷（期）: 2009,（1）
• 页码范围: 3-7
• 页数: 5页
• 分类号: R457

摘要

Stem cell therapy is not a new field, as indicated by the success of hematopoietic stem cell reconstitution for various hematological malignancies and immune-mediated disorders. In the case of tissue repair, the major issue is whether stem cells should be implanted, regardless of the type and degree of injury. Mesenchymal stem cells have thus far shown evidence of safety, based on numerous clinical trials, particularly for immune-mediated disorders. The premise behind these trials is to regulate the stimulatory immune responses negatively. To apply stem cells for other disorders, such as acute injuries caused by insults from surgical trauma and myocardial infarction, would require other scientific considerations. This does not imply that such injuries are not accompanied by immune responses. Indeed, acute injuries could accompany infiltration of immune cells to the sites of injuries. The implantation of stem cells within a milieu of inflammation will establish an immediate crosstalk among the stem cells, microenvironmental molecules, and resident and infiltrating immune cells. The responses at the microenvironment of tissue injury could affect distant and nearby organs. This editorial argues that the microenvironment of any tissue injury is a key consideration for effective stem cell therapy.