干细胞显型上的 nanotopography 的效果

• 作者: Rajeswari Ravichandran Clarisse CH Ng Casey K Chan Michael Raghunath Seeram Ramakrishna
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 生物学
• 关键词: Stem cells NANOFIBERS NANOTOPOGRAPHY BIOMATERIALS EXTRACELLULAR MATRIX DIFFERENTIATION
• 年，卷（期）: 2009,（1）
• 页码范围: 55-66
• 页数: 12页
• 分类号: Q813

摘要

Stem cells are unspecialized cells that can self renew indefinitely and differentiate into several somatic cells given the correct environmental cues.In the stem cell niche,stem cell-extracellular matrix(ECM)interactions are crucial for different cellular functions,such as adhesion,proliferation,and differentiation.Recently, in addition to chemical surface modifications,the importance of nanometric scale surface topography and roughness of biomaterials has increasingly becoming recognized as a crucial factor for cell survival and host tissue acceptance in synthetic ECMs.This review describes the influence of nanotopography on stem cell phenotypes.