TRPM8与前列腺癌:过表达还是抑制,这是个问题-对本期《TRPM8对前列腺癌PC-3细胞增殖和迁移能力影响的研究》一文的评论

• 作者: Prakash Kulkami
• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2009,（2）
• 所属期刊栏目: 热点评论
• 页码范围: 150-151
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2009.13

摘要

The progression of cells from a normal differentiated state in which the rates of proliferation and apoptosis are in check, to a tumorigenic and metastatic state where these rates are imbalanced, likely involves the accumulation of mutations in multiple genes, and the evolution and clonal selection of more aggressive phenotypes. These events are associated with changes in the expression of numerous gene products including the transient receptor potential (TRP) proteins. TRP proteins are a family of Ca2～- and Na+-permeable channels that play a diverse and important role in cellular physiology and pathology. One member of this family, TRPM8, a receptor-activated non-selective cation channel is highly expressed in prostate cancer (PCa) cells and in recent years, has emerged as a promising prognostic marker and putative therapeutic target in PCa.