RELATIONSHIP BETWEEN VARIOUS CHINESE MEDICINE TYPES AND T-CELL SUBSETS IN PATIENTS WITH ULCERATIVE COLITIS

• 来源期刊: 中国结合医学杂志(英文版)
• 学科: 医学
• 年，卷（期）: 2009,（3）
• 页码范围: 220-223
• 页数: 4页
• 分类号: R259
• 语种: 中文

摘要

Objective:To investigate the relationship between various Chinese medicine(CM) types and T-cell subsets(CD4~+ and CD8~+) in the colonic mucous membranes of patients with ulcerative colitis(UC).Methods: Fifty UC patients were enrolled,after differentiation into four types by CM syndromes,i.e.,the internal heat-damp accumulation type(IHDA),the qi-stagnancy with blood stasis type(QSBS),the Pi(脾)-Shen(肾) yang-deficiency type(PSYD) and the yin-blood deficiency type(YBD).From every patient,3-5 pieces of intestinal mucous membrane tissues were taken through colonoscopy to determine the levels of the T-cell subsets(CD4~+ and CD8~+) using immunohistochemical method.The results were compared with those in the normal control.Results: The level of CD8~+ increased and the ratio of CD4~+/CD8~+ decreased mainly in colonic mucous membranous tissues in UC patients.The level of CD4~+ decreased significantly in IHDA types(P<0.01),but decreased only slightly in the PSYD,QSBS and YBD types.CD8~+ increased significantly in the IHDA types(P<0.01),but only slightly in the other three types.Conclusion:The IHDA types of UC are closely related with T-cell subsets.The difference of T-cell subsets in various IHDA types of UC patients has provided a theoretical basis for syndrome differentiation in the CM typing of UC.