Stochasticity in the yeast mating pathway

• 来源期刊: 中国物理B（英文版）
• 关键词: noise stochastic simulation pheromone response mating pathway of yeast
• 年，卷（期）: 2009,（5）
• 页码范围: 2082-2095
• 页数: 14页
• 语种: 英文

摘要

We report stochastic simulations of the yeast mating signal transduction pathway. The effects of intrinsic and external noise, the influence of cell-to-cell difference in thc pathway capacity, and noise propagation in the pathway have been examined. The stochastic temporal behaviour of the pathway is found to be robust to the influence of inherent fluctuations, and intrinsic noise propagates in the pathway in a uniform pattern when the yeasts are treated with pheromones of different stimulus strengths and of varied fluctuations. In agreement with recent experimental findings, extrinsic noise is found to play a more prominent role than intrinsic noise in the variability of proteins. The occurrence frequency for the reactions in the pathway are also examined and a more compact network is obtained by dropping most of the reactions of least occurrence.