COMPUTATIONAL PHARMACOLOGY STUDY OF TOUGU XIAOTONG GRANULE(透骨消痛颗粒) IN PREVENTING AND TREATING KNEE OSTEOARTHRITIS

• 来源期刊: 中国结合医学杂志(英文版)
• 学科: 医学
• 关键词: 颗粒 透骨消
• 年，卷（期）: 2009,（5）
• 页码范围: 371-376
• 页数: 6页
• 分类号: R274.9
• 语种: 中文

摘要

Objective:To study the pharmacological properties of Tougu Xiaotong Granule(透骨消痛颗粒, TGXTG) in preventing and treating knee osteoarthritis(KOA) at the molecular level.Methods:The computational methods,including principal component analysis,molecular docking,target-ligand space distribution,and the predictions of absorption,distribution,metabolism,excretion and toxicity(ADMET),were introduced to characterize the molecules in TGXTG.Results:The structural properties of molecules in TGXTG were more diverse th...