Reverberatory activity in neuronal networks in vitro

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2009,（11）
• 页码范围: 1828-1835
• 页数: 8页
• 语种: 英文
• DOI: 10.1007/s11434-009-0135-1

摘要

It has been proposed that during cognitive processes, "online" memory traces in the brain are carried by reverberatory activity in neuronal circuits. However, the nature of such reverberation has remained elusive from experimental studies, largely due to the enormous complexity of intact circuits. Recent works have attempted to address this issue using cultured neuronal network and have revealed new dynamic properties of network reverberation as well as the underlying cellular mechanisms. These results demonstrate the effectiveness of in vitro networks as a useful tool for mechanistic dissection of neuronal circuit dynamics.