Mechanochemical Coupling of Kinesin Studied with a Neck-Linker Swing Model

• 来源期刊: 理论物理通讯（英文版）
• 年，卷（期）: 2009,（6）
• 页码范围: 1143-1148
• 页数: 6页
• 语种: 英文

摘要

A neck-linker swing model has been proposed in this work to investigate the mechanochemical coupling of kinesin. The difference between force-velocity curves given by force clamp and fixed trap respectively has been satisfactorily interpreted by this model. The study implies that ADP releasing and ATP hydrolysis are much less force-dependent in force clamp experiments than that in fixed trap experiments in the regime of moderate loading force, which might be a consequence of the delayed response of servo system in force clamp experiments.