Synthesis and micellization behavior of stimuli-responsive polypeptide hybrid triblock copolymer

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2009,（11）
• 页码范围: 1912-1917
• 页数: 6页
• 语种: 英文
• DOI: 10.1007/s11434-009-0244-x

摘要

Polypeptide hybrid triblock copolymer, poly(L-glutamic acid)-b-poly(propylene oxide)-b-poly (L-gluo tamic acid) (PLGA-b-PPO-b-PLGA), was synthesized by the ring-opening polymerization of benzyI-L-glutamic N-carboxyanhydride (BLG-NCA) using poly(propylene glycol) bis(2-aminopropyl ether) as initiator, followed by the subsequent deprotection step. The obtained double hydrophilic triblock co-polymer exhibits "schizophrenic" micellization behavior in aqueous solution upon dually playing with solution pH and temperature. The multi-responsive micellization behavior of this poiypeptide hybrid triblock copolymer has been thoroughly investigated by 1H NMR, laser light scattering (LLS), tempera-ture-dependent optical transmittance, and circular dichroism spectroscopy (CD).