Preparation, characterization and release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA

• 来源期刊: 科学通报(英文版)
• 学科: 工学
• 关键词: 二氧化硅 纳米粒子 甲基紫精 输送系统 PLGA 双壳 透射电子显微镜 可生物降解
• 年，卷（期）: 2010,（3）
• 所属期刊栏目: ARTICLES
• 页码范围: 263-267
• 页数: 5页
• 分类号: TQ127.2 TB383
• 语种: 英文

摘要

The use of nanotechnology in drug delivery is a rapidly expanding field. Biodegradable or nontoxic nanomaterials have the most promising application potentials in nanomedicine. Herein, we report a novel core-shell nanoparticle with double shell coatings (silica and poly(D,L-lactide-co-glycolide) (PLGA)) with the total shell thickness of (8.7 ± 1.3) nm. The outer shell of PLGA is biodegradable and used for controlled and sustained release, and the inner shell of silica is mesoporous for the preservation of t...