人的 pluripotent 干细胞: 从生物学到房间治疗

• 作者: Jean-Marie Ramirez Marilyne Dijon-Grinand Said Assou Sabine Gerbal-Chaloin Samir Hamamah John De Vos
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: PLURIPOTENT STEM CELLS Embryonic STEM CELLS THERAPEUTICS CELL REPROGRAMMING CELL proliferation CELL differentiation
• 年，卷（期）: 2010,（2）
• 页码范围: 24-33
• 页数: 10页
• 分类号: R457

摘要

Human pluripotent stem cells(PSCs),encompassing embryonic stem cells and induced pluripotent stem cells,proliferate extensively and differentiate into virtually any desired cell type.PSCs endow regenerative medicine with an unlimited source of replacement cells suitable for human therapy.Several hurdles must be carefully addressed in PSC research before these theoretical possibilities are translated into clinical applications.These obstacles are:(1) cell proliferation;(2) cell differentiation;(3) genetic integrity;(4) allogenicity;and(5) ethical issues.We discuss these issues and underline the fact that the answers to these questions lie in a better understanding of the biology of PSCs.To contribute to this aim,we have developed a free online expression atlas,Amazonia!,that displays for each human gene a virtual northern blot for PSC samples and adult tissues(http://www.amazonia.transcriptome.eu).