为尖锐的肝失败的新治疗策略

• 作者: Kazuhiro Kotoh Makoto Nakamuta Masaki Kato Motoyuki Kohjima Munechika Enjoji
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: ACUTE liver FAILURE STEROIDS MACROPHAGES HEPATITIS FERRITIN
• 年，卷（期）: 2010,（11）
• 页码范围: 395-400
• 页数: 6页
• 分类号: R575.3

摘要

Acute liver failure (ALF) is a syndrome def ined by coa g ulopathy and encephalopathy and no effective treat ments have been established, except for liver transplantation. However, considering the limited supply of donors, we should endeavor to prevent the progre ssion of this syndrome in its early stage to improve the prognosis of patients with ALF. Recently, several authors have reported that over-activation of intrahepatic macrophages plays an important role in the progression of ALF and we have developed a new treatment method, transcatheter arterial steroid injection therapy (TASIT), to suppress macrophage activation. We have now used TASIT for 5 years and have found that TASIT is effective for patients with over-activation of macrophages in the liver but not for those with les ser activation of macrophages. Therefore, to identify the most appropriate patients for TASIT, we tried to categorize patients with ALF or acute liver injury according to markers for the degree of intrahepatic macrophage activation. This approach was helpful to select the appro-priate treatment including liver transplantation. We believe that it is essential to analyze disease progression in each patient before selecting the most appropriate treatment.