Drosophila as a model for antiviral immunity

• 作者: Mika Rmet Susanna Valanne
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: ANTIVIRAL DROSOPHILA GENETICS IMMUNE signaling Infection JAK/STAT RNA INTERFERENCE Virus
• 年，卷（期）: 2010,（5）
• 页码范围: 151-159
• 页数: 9页
• 分类号: R392.1

摘要

The fruit fly Drosophila melanogaster has been successfully used to study numerous biological processes including immune response.Flies are naturally infected with more than twenty RNA viruses making it a valid model organism to study host-pathogen interactions during viral infections.The Drosophila antiviral immunity includes RNA interference,activation of the JAK/STAT and other signaling cascades and other mechanisms such as autophagy and interactions with other microorganisms.Here we review Drosophila as an immunological research model as well as recent advances in the field ofDrosophila antiviral immunity.