Nuclear Model Calculations on the Production of Auger Emitter 165Er for Targeted Radionuclide Therapy

• 作者: Claudio Tenreiro Mahdi Sadeghi Milad Enferadi
• 来源期刊: 现代物理(英文)
• 学科: 医学
• 关键词: 165Er AUGER Electron EXCITATION FUNCTIONS TALYS-1.2 ALICE-ASH
• 年，卷（期）: 2010,（4）
• 页码范围: 217-225
• 页数: 9页
• 分类号: R73

摘要

Auger electron emitting radionuclides have potential for the therapy of small-size cancers because of their high level of cytotoxicity, low-energy, high linear energy transfer, and short range biologic effectiveness. Auger emitter 165Er (T1/2 = 10.3 h, IEC = 100%) is a potent nuclide for targeted radionuclide therapy. 165Er excitation function via 165Ho(p,n)165Er, 165Ho(d,2n)165Er, 166Er(p,2n)165Tm→165Er, 166Er(d,3n)165Tm→165Er, natEr(p,xn)165Tm→165Er and 164Er(d,n)165Tm→165Er reactions were calculated by ALICE/91, ALICE/ASH (GDH Model & Hybrid Model) and TALYS-1.2 (Equilibrium & Pre-Equilibrium) codes and compared to existing data. Requisite for optimal thicknesses of targets were obtained by SRIM code for each reaction.