Which is the best choice for gastroesophageal disorders:Melatonin or proton pump inhibitors?

• 作者: Joanna Dulce Favacho de Oliveira Torres Ricardo de Souza Pereira
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: MELATONIN Sleep disorder GASTROESOPHAGEAL REFLUX disease OMEPRAZOLE ULCERS GASTRITIS
• 年，卷（期）: 2010,（5）
• 页码范围: 102-106
• 页数: 5页
• 分类号: R573

摘要

Melatonin is used in many countries to improve sleep disorders.Melatonin is a hormone produced by the pineal gland and enterochromaff in cells which control sleep and gastrointestinal motility.Low levels of melatonin lead to gastroesophageal reflux disease(GERD).Most of patients with GERD have a sleep disorder.So,low melatonin levels is the main cause of insomnia.Beyond this,it has an inhibitory action on gastric acid secretion and seems to control the lower esophageal sphincter.Proton pump inhibitors(PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production.They are the most potent inhibitors of acid secretion available today.Omeprazole(one of the PPIs) and melatonin have similarities in their chemical structures.Therefore,we could consider omeprazole as a rough copy of melatonin.In this paper,we compare the advantages and disadvantages of the clinical use of melatonin and PPIs.