在血液的传播 galectin-3 : 癌症的一个新兴的倡导者转移

• 作者: Lu-Gang Yu
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: CIRCULATING GALECTIN-3 CANCER cell adhesion CANCER DISSEMINATION METASTASIS
• 年，卷（期）: 2010,（4）
• 页码范围: 177-180
• 页数: 4页
• 分类号: R730.2

摘要

Increased concentrations of free circulating galectin-3 are commonly seen in the blood circulation of patients with many types of cancers including colorectal cancer.Recent studies have shown that changes in circulating galectin-3 levels in cancer patients may contribute significantly to the metastatic spread of disseminating cancer cells by enhancing their ability to adhere to blood vessel endothelium and by helping their avoidance of immune surveillance.Thus,targeting the galectin-3 actions in the circulation may hold significant promise for future development of novel therapeutic agents to prevent metastasis and reduce cancer-associated fatality.