Optimised NSAIDs-loaded Biocompatible Nanoparticles

• 来源期刊: 纳微快报(英文版)
• 学科: 工学
• 关键词: Drug delivery systems(DDS) Biocompatible Emulsion-solvent diffusion method PLGA Glycofurol Non steroidal anti-inflammatory drugs(NSAIDs)
• 年，卷（期）: 2010,（4）
• 页码范围: 247-255
• 页数: 9页
• 分类号: TQ460.1
• 语种: 中文

摘要

In this formulation study,biocompatible non steroidal anti-inflammatory(NSAIDs)-loaded nanoparticles were designed as models to be further integrated in a prosthesis surface functionalization.A modified spontaneous emulsion-solvent diffusion methodology was used to produce drug-loaded PLGA nanoparticles without any purification or solvent evaporation requirements.Formulation parameters,such as lactide/glycolide ratio,polymer concentration,solvent/non solvent ratio and non solvent phase,as well as the non ionic tensioactive P188 co-precipitation composition were systematically explored.The optimized formulation(mean size:145 nm,surface charge:-13 m V) was employed to encapsulate various amounts of NSAIDs in a simple and scalable manner.The drug release was characterized in vitro by a complete release for 48 h.These results encourage upcoming preliminary steps for in vivo experiments of prosthesis surface functionalization.