在有长期的肝炎 B 的病人的 hepatocellular 癌的风险上的抗病毒的治疗的效果

• 作者: Konstantinos Tziomalos
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Chronic hepatitis B HEPATOCELLULAR carcinoma Interferon LAMIVUDINE ADEFOVIR TELBIVUDINE ENTECAVIR TENOFOVIR
• 年，卷（期）: 2010,（3）
• 页码范围: 91-93
• 页数: 3页
• 分类号: R735.7

摘要

Chronic hepatitis B (CHB) is a major risk factor for hepatocellular carcinoma (HCC). The prevention of HCC is of paramount importance in patients with CHB, particularly in those with cirrhosis. Antiviral treatment can potentially reduce the risk for HCC since it suppresses viral replication, induces HBeAg seroconversion and improves liver histology. However, most evidence supporting a protective effect of antiviral treatment originates from non-randomized or retrospective studies and is limited to conventional interferon and lamivudine. There is a paucity of data on the effects of pegylated interferon and 'newer' oral agents (telbivudine, tenofovir, entecavir) on HCC risk. However, it should be emphasized that the existing randomized control studies in patients with CHB were relatively short-term and not designed to assess the effects of antiviral treatment on HCC risk. Since viral load directly correlates with HCC risk, it is reasonable to hypothesize that the reduction in viral load with antiviral treatment will also lower the risk of HCC. This benefit might become more readily apparent with the newer agents used in the management of CHB which are more effective and have a more favorable resistance profile.