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摘要:
Even though Sorafenib has radically changed the natural history of those hepatocellular carcinoma patients who are not amenable for curative treatments, further therapeutic improvements are badly needed. As it was for Sorafenib, our increasingly refined understanding of the complex mechanisms underlying HCC carcinogenesis are the starting point for the future development of such treatments. Presently, a number of molecularly targeted agents are in different stages of development for this once orphan cancer. Indeed, several pathways are presently being explored to identify potentially active drugs, including epidermal growth factor receptor, vascular endothelial growth factor/vascular endothelial growth factor receptors, mammalian target of rapamycin, phosphatidyl-inositol-3-kinase/Akt, insulin growth factor, Aurora kinase, Wnt/β-catenin, retinoic acid receptor and hepatocyte growth factor/C-Met. This review is aimed at addressing the results obtained so far with these newer drugs, also considering the challenges we shall face in the near future, including the issue of response evaluation and identification of predictive/ prognostic biomarkers.
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篇名 Medical treatment of unresectable hepatocellular carcinoma: Going beyond sorafenib
来源期刊 世界肝病学杂志:英文版(电子版) 学科 医学
关键词 HEPATOCELLULAR carcinoma Molecularly TARGETED agents Molecular PATHWAYS
年,卷(期) 2010,(3) 所属期刊栏目
研究方向 页码范围 103-113
页数 11页 分类号 R735.7
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HEPATOCELLULAR
carcinoma
Molecularly
TARGETED
agents
Molecular
PATHWAYS
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世界肝病学杂志:英文版(电子版)
月刊
1948-5182
北京市朝阳区东四环中路62号楼远洋国际中
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381
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0
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