intracranial 动脉粥样硬化患者疾病的自然历史上的更改: 批评评论

• 作者: Christopher P Kellner Daniel M Raper Dorothea Strozyk Philip M Meyers Randall T Higashida Ricardo J Komotar
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: INTRACRANIAL ATHEROSCLEROSIS NATURAL HISTORY STENOSIS
• 年，卷（期）: 2010,（5）
• 页码范围: 166-171
• 页数: 6页
• 分类号: R743

摘要

Intracranial atherosclerotic disease (ICAD) contributes to a significant number of ischemic strokes. There is debate in the recent literature concerning the impact of the location of stenosis in ICAD on outcome. Some reports have suggested that disease processes and outcomes vary by vessel location, potentially altering the natural history and indications for intervention. Here we have performed a comprehensive, critical review of the natural history of ICAD by vessel in an attempt to assess the differences in disease specific to each of the vascular territories. Our assessment concludes that only minor differences exist between patients with different vessels affected in vessel-specific ICAD. We have found that middle cerebral artery disease confers a lower mortality than vessel-specific ICAD in other intracranial vessels, asymptomatic disease follows a more benign course than symptomatic disease, andthat plaque progression or the detection of microemboli on transcranial Doppler may predict poor outcome. Given the expanding indications for treatment of ICAD and rapidly developing endovascular techniques to confront this disease, a thorough understanding of the natural history of ICAD aids the interventional neuroradiologist in determining when to treat and how to predict outcome in this patient population.