在有 hepatocellular 癌的病人的 Alpha-fetoprotein 特定的 CD4 和 CD8 T 房间回答

• 作者: Shahriar Behboudi Stephen P Pereira
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: HEPATOCELLULAR carcinoma ALPHA-FETOPROTEIN Cell-mediated IMMUNITY IMMUNOTHERAPY
• 年，卷（期）: 2010,（7）
• 页码范围: 256-260
• 页数: 5页
• 分类号: R735.7

摘要

The presence of CD8 T cell responses to tumor associated antigens have been reported in patients with different malignancies. However, there is very little inf ormation on a comparable CD8 and CD4 T cell response to a tumor antigen in liver cancer patients. Here, we re-examine the kinetic and the pattern of T helper 1 and cytotoxic T lymphocyte responses to alpha-fetoprotein (AFP),a tumor rejection antigen in hepatocellular carcinoma (HCC). Then, we discuss the possibility of using AFP-based immunotherapy in combination with necrotizing treatments in HCC patients.