由肝的动脉的注入治疗为的成功的治疗进展， unresectable 胆汁的道癌症

• 作者: Masako Nishimura
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Hepatic arterial infusion GEMCITABINE CISPLATIN INTRAHEPATIC CHOLANGIOCARCINOMA GALLBLADDER cancer
• 年，卷（期）: 2010,（5）
• 页码范围: 192-197
• 页数: 6页
• 分类号: R735.8

摘要

Biliary tract cancers(BTC)are relatively rare tumors, and the prognosis is extremely poor.There has been no standard chemotherapy for advanced BTC.However, recently,gemcitabine(GEM)have been used against BTC as the most active agent,and promising response rates and overall survival times with tolerable drug toxicities have been observed.In this article,two cases of advanced intrahepatic cholangiocarcinoma and unresectable metastatic gallbladder(GB)cancer are reported.They were treated with hepatic arterial infusion(HAI)chemotherapy using a combination of GEM and cisplatin,along with the systemic administration of GEM.As a consequence,multiple liver tumors,the GB cancer and metastatic lymph nodes regressed without severe drug toxicities,and favorable results(the overall survival times were 16 and 14 mo, respectively)were achieved.In conclusion,HAI therapy using GEM combined with cisplatin may be a useful and well-tolerated option for advanced BTC,especially in cases where multiple liver metastases are detected.