The toxic effect of solubilizing excipients on Tetrahymena thermophila BF5 growth investigated by microcalorimetry

• 来源期刊: 科学通报(英文版)
• 学科: 工学
• 关键词: 生长速率常数 嗜热四膜虫 毒性作用 辅料 聚乙二醇400 微量热 抑制浓度 ramp
• 年，卷（期）: 2010,（18）
• 页码范围: 1870-1876
• 页数: 7页
• 分类号: TS262.5 TQ021
• 语种: 英文

摘要

The toxic effect of different solubilizing excipients on the growth and metabolism of Tetrahymena thermophila BF5(T.t.BF5) at various concentrations was investigated by microcalorimetry.The thermogenic curves of T.t.BF5 growth were determined at 28°C,and were evaluated by dynamic parameters.The results indicated that the values of growth rate constant(k),maximum power(P1,P2),peak time(T1,T2) and total quantity of heat(Q) varied for different excipients.There was a good linear relationship between k and concentrations(r0.95,P