Chiral pyrrolidine-azole conjugates: Simple and efficient asymmetric organocatalysts for Michael addition to nitrostyrenes

• 来源期刊: 科学通报(英文版)
• 学科: 化学
• 关键词: 不对称Michael加成 有机催化剂 吡咯烷 迈克尔 复合物 三氮唑 手性 高效催化剂
• 年，卷（期）: 2010,（17）
• 所属期刊栏目: ARTICLES
• 页码范围: 1735-1741
• 页数: 7页
• 分类号: O626.13 TQ654.2
• 语种: 英文

摘要

Simple pyrrolidine-azole conjugates have been synthesized and found to be efficient catalysts for asymmetric Michael addition to nitrostyrenes. The identified optimal catalysts, pyrrolidine-azoles 2, 8 and 13, could catalyze the asymmetric Michael addition of a range of Michael donors and nitrostyrenes in high yields (up to 99%) and excellent stereoselectivities (up to 99:1 dr and 97%ee).