Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells

• 作者: 李丛鑫 王渭池 王鹏业 陈晓芳
• 来源期刊: 中国物理快报(英文版)
• 学科: 生物学
• 关键词: T细胞 时空格局 通道 作者 反应扩散模型 调制方式 活性钙 恒温恒湿
• 年，卷（期）: 2010,（2）
• 页码范围: 311-314
• 页数: 4页
• 分类号: Q149 S858.31
• 语种: 英文

摘要

A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2+ dynamics under the effects of Ca2+-release activated Ca2+ (CRAC) channels in T cells. Simulation results show a strong dependence of the modulation mode of Ca2+ oscillation and dynamic patterns of Ca2+ wave on the influx rate through the CRAC channel (ksoc). When ksoc is small, cytoplasmic Ca2+ is modulated as a frequency-modulation (FM) signal, whereas it shows an amplitude modulation (AM) mode after ksoc passes through a critical value. The heterogeneity in spatial Ca2+ distribution is mostly arising from the influx through CRAC channels in both FM and AM modes. During each Ca2+ spike, a more sustained cytoplasmic Ca2+ gradient is maintained in the AM mode rather than in the FM mode.