In vivo whole-body imaging of optical agent dynamics using full angle fluorescence diffuse optical tomography

• 来源期刊: 中国光学快报(英文版)
• 学科: 工学
• 关键词: 光学成像 体内动态 荧光成像 断层扫描 扩散 断层图像 代谢过程 时间尺度
• 年，卷（期）: 2010,（12）
• 所属期刊栏目: Medical Optics and Biotechnology
• 页码范围: 1156-1159
• 页数: 4页
• 分类号: TP334.22 TS218
• 语种: 英文

摘要

Dynamic fluorescence diffuse optical tomography (FDOT) is important in drug deliver research. In this letter, we first image the metabolic processes of micelles indocyanine green throughout the whole body of a nude mouse using the full-angle FDOT system with line illumination (L-FDOT). The resolution of L-FDOT is evaluated using phantom experiment. Next, in vivo dynamic tomographic images (100 frames; approximately 170 min) of mouse liver and abdomen are shown and cross-validated by planar fluorescence reflectance imaging in vitro. Results provide evidence on applicability of the tomographic image wholebody biological activities in vivo on minute timescale (approximately 1.7 min) using L-FDOT.