Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population

• 来源期刊: 世界胃肠病学杂志(英文版)
• 学科: 医学
• 年，卷（期）: 2010,（28）
• 页码范围: 3578-3583
• 页数: 6页
• 分类号: R735.2
• 语种: 中文

摘要

AIM:To investigate the association between pre-miR- 146a C/G polymorphism and gastric cancer risk. METHODS:We performed a hospital-based,case-control study using polymerase chain reaction-restriction fragment length polymorphism method in 608 individuals(304 gastric cancer patients and 304 age and sex matched cancer-free controls).RESULTS:The frequencies of pre-miR-146a C/G genotypes in the case group were significantly different from those in the control groups(P=0.037).Compared with CC genotype carriers,subjects with the variant genotypes(GC+GG)had a 58%increased risk of gastric cancer(adjusted OR=1.58,95%CI:1.11-2.20,P= 0.009).Moreover,a higher gastric cancer risk was especially evident in younger individuals aged≤58 years, nonsmokers,and males(adjusted OR=1.76,95%CI: 1.08-2.87,P=0.024;adjusted OR=1.55,95%CI: 1.06-2.28,P=0.025;adjusted OR=1.53,95%CI: 1.04-2.27,P=0.033;respectively). CONCLUSION:Pre-miR-146a C/G polymorphism might be associated with an elevated risk of gastric cancer in Chinese population.