Synergistic Effect of Auto-Activation and Small RNA Regulation on Gene Expression

• 来源期刊: 中国物理快报（英文版）
• 年，卷（期）: 2010,（9）
• 页码范围: 237-240
• 页数: 4页
• 语种: 英文
• DOI: 10.1088/0256-307X/27/9/098701

摘要

Auto-activation and small ribonucleic acid(RNA)-mediated regulation are two important mechanisms in controlling gene expression.We study the synergistic effect of these two regulations on gene expression.It is found that under this combinatorial regulation,gene expression exhibits bistable behaviors at the transition regime,while each of these two regulations,if working solely,only leads to monostability.Within the stochastic framework,the base pairing strength between sRNA and mRNA plays an important role in controlling the transition time between on and off states.