Early anesthetic exposure and long-term cognitive impairment

• 作者: Feng Tao
• 来源期刊: 世界实验医学杂志
• 学科: 医学
• 关键词: ANESTHETICS Cognitive DYSFUNCTION PDZ interactions NEUROGENESIS SYNAPTOGENESIS
• 年，卷（期）: 2011,（1）
• 页码范围: 3-6
• 页数: 4页
• 分类号: R

摘要

Several lines of evidence from clinical cohort studies and animal studies have shown that early exposure to anesthetics is a significant risk factor for later development of learning disabilities.However,the underlying molecular mechanism is unclear.Recent studies have indicated that hippocampal neurogenesis and synaptogenesis may be involved in the mechanisms by which early anesthetic exposure produces long-term cognitive impairment.It is possible that synaptic scaffolding protein postsynaptic density-95(PSD-95)PDZ(PSD 95/Discs large/Zona occludens-1)domain-mediated protein-protein interactions are involved in the regulation of neurogenesis and synaptogenesis in the central nervous system.PDZ domain-mediated protein-protein interactions are disrupted by clinically relevant concentrations of inhaled anesthetics.It will help us understand the molecular mechanism underlying anestheticinduced long-term cognitive dysfunction if we can demonstrate the role of synaptic PDZ interactions in early anesthetic exposure-produced long-term cognitive impairment.