含酒精的肝炎的致病: 煽动性的发信号和氧化应力的角色

• 作者: Rashid Khan Sarat C Jampana
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: ALCOHOLIC hepatitis LIPOPOLYSACCHARIDE TOLL like RECEPTORS Oxidative stress ENDOTOXIN
• 年，卷（期）: 2011,（5）
• 页码范围: 114-117
• 页数: 4页
• 分类号: R575.1

摘要

Inflammatory signaling and oxidative stress are two major components in the pathogenesis of alcoholic he-patitis.Alcohol consumption results in translocation of gut bacteria into the portal system along with lipopolysaccharides that interact with toll-like receptors and results in the production of inflammatory and immunogenic mediators such as tumor necrosis factor-alpha(TNF-α) and interferons.Chronic consumption of alcohol causes priming of this process in which there is enhanced production of cytokines,interferon,interleukins,and TNF-α.Oxidative stress,genetic predisposition,and the unfolded protein response are other contributory mechanisms.Novel therapies aimed at these pathways may prevent,decrease,or delay the complications of alcoholic hepatitis.