A Facile Synthesis of 2-Amino-5-Cyano-4, 6-Disubstitutedpyrimidines under MWI

• 作者: Kapil D. More Kishor S. Jain M. K. Kathiravan Nikhil S. More Sachin A Wakedkar Swapnil. K. Chaudhari
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: MICROWAVE Assisted Organic Synthesis (MAOS) 2-Amino-5-Cyano-2 6-Disubstitutedpyrimidines Α-Cyanoketene S S-ACETALS
• 年，卷（期）: yjhxgjqkyw,（2）
• 页码范围: 47-52
• 页数: 6页
• 分类号: O6

摘要

Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput synthesis of mononuclear 2-amino-5-cyano-4,6-disubstituted pyrimidines, adaptable to parallel synthesis for compound libraries. The overall reaction time in hrs has been reduced to 25 - 50 minutes with improved yields.