Taming of macrophage and microglial cell activation by microRNA-124
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摘要:
Microglial cells are from the myeloid lineage and are the only hematopoietic cell resident to the central nervous sys-tem (CNS). They populate the CNS during development and are located throughout the CNS. In the adult, micro-glial cells are maintained in a quiescent state exhibiting a ramified morphology.These resting microglial cells are char-acterized by a CD45lo phenotype and express very low levels of the antigen presentation molecules MHC class Ⅱ, B7.2 and CD40 [1]. Although quiescent, microglial cells are dynamic constantly sending out processes to survey their surrounding microenvironment [2].Upon encounter with activation signals, microglial cells are able to rapidly respond by changing both morphologi-cally and phenotypicaily.