无征状的主要胆汁的肝硬化没与心血管的疾病的增加的频率被联系

• 作者: Cynthia Levy Iliana Doycheva Jen-Jung Pan
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: HYPERLIPIDEMIA CARDIOVASCULAR disease ASYMPTOMATIC primary BILIARY CIRRHOSIS FATIGUE
• 年，卷（期）: 2011,（4）
• 页码范围: 93-98
• 页数: 6页
• 分类号: R575.2

摘要

AIM:To estimate the prevalence of cardiovascular events in Primary biliary cirrhosis(PBC) and to determine whether this risk is higher within specific subgroups of patients with PBC. METHODS:We included 180 patients with PBC(cases) and 151 patients seen for HCV infection(controls) .Medical records were reviewed and statistical analyses were performed as appropriate. RESULTS:When compared to controls,PBC patients were older,leaner and had higher serum levels of total cholesterol,high density lipoprotein and low density cholesterol.There were more females in the PBC group(91.7%vs 43%,P【0.001) .More control subjects had smoked than the PBC patients(63.6%vs 35%,P 【0.001) .The prevalence of hypertension,diabetes,coronary artery disease and stroke was similar between the two groups.Seven percent of controls and 10%of cases developed any type of cardiovascular disease(P =0.3) .Only 36.7%were asymptomatic at diagnosis. Three cardiovascular events were documented amongasymptomatic patients(4.5%) and fifteen among symptomatic patients(13.2%;P=0.06) .Among PBC patients with fatigue,10(13.5%) had a cardiovascular event compared to 7(6.7%) among patients without fatigue(P=0.1) . CONCLUSION:Asymptomatic PBC patients do not have a greater frequency of cardiovascular disease;nor do patients suffering with fatigue.