象生长因素一样的浆液胰岛素的关联 -- 我与在马来西亚怀孕糖尿病患者的 retinopathy

• 作者: A M Zaleha I Tajunisah M Muhaya M Normalina S Adzura W P Sharifa Ezat
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: DIABETIC RETINOPATHY PREGNANCY SERUM IGF-1 level
• 年，卷（期）: 2011,（1）
• 页码范围: 69-72
• 页数: 4页
• 分类号: R714.256

摘要

AIM:To study the association of serum insulin-like growth factor-I(IGF-I) with diabetic retinopathy.· METHODS:Serum IGF-1 levels were measured in 25 pregnant diabetic patients and 25 pregnant non-diabetic patients who were matched for age,ethnicity,parity and period of gestation.Fundus examination was performed in both groups at 28,32 and 36 weeks of gestation.RESULTS:The serum IGF-I level was significantly elevated in pregnant diabetics compared to pregnant non-diabetics(366±199μg/L vs 184±89μg/L,(P=0.0001) at 24 weeks,535±251μg/L vs 356±89μg/L,(P=0.007) at 32 weeks and 404±166μg/L vs 264±113μg/L,(P=0.003) at 36 weeks of gestation).The pregnant diabetics with established diabetes had significantly higher IGF-1 level than gestational diabetes at 28,32 and 36 weeks of gestation.The serum IGF-I level in pregnant diabetics with retinopathy was significantly higher than in those without retinopathy at all periods of gestation.· CONCLUSION:Increased serum IGF-1 in pregnancy may increase the risks for retinopathy.